2) Atletico Madrid 4-0 Real Madrid, La Liga 2014-15
Real Madrid were the La Liga leaders at that moment, but the whole team was injury-struck. Sergio Ramos, Pepe, Marcelo, James Rodriguez and Luka Modric – all of them were missing from the squad listed for the derby. And Atletico Madrid took full advantage of the situation as Real Madrid suffered their heaviest defeat in over four years. Portuguese midfielder Tiago opened the scoring in the 14th minute, as Real Madrid failed to clear a cross. Saul put Atletico in cruise control with a second just four minutes later with a superb overhead kick. Then the new signings Antoine Griezmann and Mario Mandzukic scored the third and fourth goals respectively to give Atletico their biggest victory in 27 years over Real Madrid.