The Cincinnati Reds have not won the title for 73 years(1949-2021) now.
The Toronto Blue Jays have not won any title since 1961, making it a 61-year drought.
Milwaukee Brewers has not won any title in 53(1969-2021) years.
San Diego Padres have not clinched any World Series title since 1969, leading to a 53 years drought.
Since 1977, Seattle Mariners have not taken home the World Series trophy. (45 years)