The Arizona Cardinals tried to mount a comeback, but the Colts held on for a tense 31-27 win. After falling behind in the first half, quarterback Jacoby Brissett connected with tight end Trey McBride for a one-yard touchdown, capping a 10-play, 61-yard drive to open the second half.

The Cardinals seemed poised to close the gap, but another gut-wrenching defeat slipped through their fingers in the final minute. McBride didn’t hold back after the game. He insisted he was held on a critical fourth-down pass in the end zone, a no-call that ultimately sealed the Cardinals’ fate. Even amid his frustration with the referees, McBride quickly pivoted to praise his teammates.

He highlighted how backup players stepped up without missing a beat, showing the depth and resilience of the roster despite the loss. Arizona’s offense, led by Brissett and McBride, recorded a season-best 400 yards.Yet the effort still fell short.

Chad Ryland’s extra point gave the Cardinals a 17–14 edge midway through the third quarter. Capping a drive that showcased tight end Trey McBride’s growing influence. McBride hauled in three key receptions on that series alone, bringing his total to six catches for 59 yards on the day. His reliability became even more crucial after wideout Marvin Harrison Jr. was ruled out due to a concussion evaluation.

Meanwhile, a personal milestone for quarterback Jacoby Brissett—his first scoring throw as a Cardinal and the continuation of a unique NFL streak. He’s now tossed touchdowns for six different teams across his career, a testament to his adaptability.

Still, the ending stung. And while every NFL matchup features its share of tight officiating calls, this one served as a harsh reminder: the best teams find a way to take control before the game ever reaches the referee’s hands.

Trey McBride’s steady play and Jacoby Brissett’s big day

Arizona quarterback Jacoby Brissett drew the start against the Indianapolis Colts on Sunday. After the Cardinals officially ruled Kyler Murray inactive. Murray had entered the weekend listed as questionable with a lingering foot injury sustained. During the third quarter of last week’s narrow 22–21 loss to the Tennessee Titans.

Despite the uncertainty surrounding his franchise quarterback, head coach Jonathan Gannon was quick to silence any speculation about a potential changing of the guard. “For all of you who are curious: Kyler Murray is still the Cardinals’ starting quarterback,” Gannon confirmed, per a post-game report by ESPN’s Josh Weinfuss.

Still, Brissett made the most of his opportunity. The 32-year-old veteran finished with 320 passing yards. More than Murray has thrown for in any of the team’s first five games.

Brissett aired it out 44 times in an offense that leaned heavily on the aerial attack. After being held to just 88 rushing yards. Among his favorite targets was tight end Trey McBride, who delivered another steady performance. And provided the security blanket Brissett needed in tight spots.

The Cardinals, however, remain in a rough stretch. Murray’s injury came on the heels of James Conner’s season-ending foot injury, stripping the team of two offensive cornerstones. At 2–4, Arizona continues to struggle to establish an identity under Gannon’s leadership.

For now, all signs point to Murray returning in Week 7 when the Cardinals face the Green Bay Packers at home before their Week 8 bye.