The first month of the 2025 NFL season is behind us, and as the calendars turn over to October, the season really starts to ramp up. There are a number of notable matchups in Week 5, including Cowboys at Jets, Broncos at Eagles, Commanders at Chargers and Chiefs at Jaguars.

The 49ers already took down the Rams on Thursday night to open the week, but we’re going to go through the rest of Week 5’s schedule and predict the outcome for every single game on the slate.

Vikings (-3.5) at Browns (London)

Luke Hubbard, NFL Content Writer: The weekend kicks off with the Vikings and Browns taking a trip to London. Both teams will be without their starting quarterback, but my attention will be on Dillon Gabriel. The rookie is making his first NFL start against Brian Flores, who is notorious for his exotic pressures. The Vikings’ defense will be too much for Gabriel to handle, and Minnesota wins fairly easily.

Vikings 17, Browns 10

Tim Wood, NFL Content Chief: Wentz has a respectable game but Gabriel on offense and Garrett on D too much for Vikes in London.

Browns 26, Vikings 23

Abhisek Singh, NFL Content Manager: Both teams are similar with good defenses but poor offenses. It’ll be a low-scoring affair with Carson Wentz handing Dillon Gabriel a defeat in his NFL debut.

Vikings 10, Browns 9

Cowboys (-2.5) at Jets

Hubbard: The Cowboys and Jets have two high-powered offenses that are capable of putting a lot of points on the board. Defensively, both squads have struggled, giving up over 30 points per game. This should be a shootout, and while it’ll be close, Dak Prescott gets the job done with a late scoring drive.

Cowboys: 35, Jets 28

Wood: Cowboys. I really didn’t want it to play out this way, folks. But the Jets are a dumpster fire and the hot seat is official now. No more safety for Aaron Glenn.

Cowboys 34, Jets 10

Singh: Easy win for the Cowboys with a confident Dak Prescott facing a struggling Jets side

Cowboys 30, Jets 9

Broncos at Eagles (-4)

Hubbard: The Broncos offense, specifically Bo Nix, has been a bit disappointing this season. They did play well last time out against the Bengals, but overall just hasn’t lived up to expectations. This week, they face a really good Eagles defense, which should be able to neutralize Nix and the rest of the Broncos offense. This will be a defensive battle, and the Eagles come out on top.

Eagles 20, Broncos 14

Wood: If this was in Denver, I might be tempted to make this Philly’s first loss. It’s coming. Just not this week.

Eagles 28, Broncos 17

Singh: It’ll be close thanks to Broncos’ defense but Eagles will stay unbeaten in Week 5. Dual threat QB Hurts will star with a solid passing game.

Eagles 23, Broncos 20

Texans (-2.5) at Ravens

Hubbard: With Lamar Jackson’s status in question, this is a tough game to pick. Jackson has not practiced this week, so it seems likely that Cooper Rush will get his first start of the year. If Jackson’s out, it’s hard to imagine the Ravens’ offense having much success against the Texans’ defense, which leads the league in points allowed. If Jackson does play, which seems like a long shot, the Ravens should win.

Texans 17, Ravens 13

Wood: Stroud and Houston offense hits stride, while Cooper Rush “hysteria” is over.

Texans 30, Ravens 13

Singh: A messy Ravens defense will fall against CJ Stroud’s offense. Cooper Rush will struggle to replace injured Lamar Jackson.

Texans 19, Ravens 17

Raiders at Colts (-7)

Hubbard: The Colts have been a pleasant surprised this season. They’re 3-1 and just lost their first game to the Rams, but they still played well. On the other side, the Raiders won their first game of the season, but have struggled on both sides of the ball since. The Raiders could keep this competitive, but the Colts should win.

Colts 31, Raiders 21

Wood: Jones and Co. back on track after a stumble last week. Raiders’ misery deepening.

Colts 33, Raiders 20

Singh: Indy continue their high flying run by beating Raiders. Daniel Jones’ O-Line has done a great work this season and with Geno Smith struggling, it should be an easy win for Colts.

Colts 20, Raiders 10

Dolphins (-1.5) at Panthers

Hubbard: Outside of a 30-0 beatdown of the Falcons, the Panthers have not looked good this season, but neither have the Dolphins. This is a matchup between two of the worst teams in the NFL, and neither team has much of an edge, so let’s ride with the home team.

Panthers 23, Dolphins 20

Wood: Nobody is losing their job over this one, but Panthers do just enough to win at home.

Panthers 24, Dolphins 23

Singh: McDaniels’ hot seat a little colder as Dolphins inch toward respectability. De’Von Achane will get going again this week.

Dolphins 17, Panthers 10

Giants at Saints (-1.5)

Hubbard: Speaking of matchups between two of the worst teams in the NFL, the Giants and Saints clash in the Superdome this weekend. The Saints looked horrible in their first three games, but hung around with the Bills last weekend. The Giants also started 0-3, but just got their first win in Jaxson Dart’s first start. The quarterback matchup will be the most entertaining part of this game, but it’s not going to be pretty.

Saints 20, Giants 13

Wood: This may the high mark of the Dart hype, but I think the G-Men win big for Nabers.

Giants: 42, Saints 10

Singh: 19 points against Bills may fool you but Saints don’t have an answer for a motivated Giants side, which will rally behind Jaxson Dart despite injuries.

Giants 20, Saints 9

Buccaneers at Seahawks (-3.5)

Hubbard: The Buccaneers, who just suffered their first loss of the season to the Eagles, will travel to Seattle to play a Seahawks team that’s on a three-game win streak. The Bucs will be without their top running back, Bucky Irving, this weekend, so they’ll have to rely on Baker Mayfield’s arm more than ever. As much as I want to pick Seattle, I just have a feeling the Bucs get this one done.

Buccaneers 28, Seahawks 27

Wood: Game of the week, in my eyes. And thankfully, no ties.

Buccaneers 38, Seahawks 34

Singh: Oddsmakers side with the Seahawks but Baker Mayfield will helps Bucs extend their record to 4-1 on the road.

Buccaneers 24, Seahawks 21

Titans at Cardinals (-7.5)

Hubbard: The Titans might be the worst team in the NFL. Their offense has been anemic through the first four weeks, and their defense has flashed at times, but overall has been quite poor. The Cardinals may be without their two top running backs, but they should have no problem beating down on the Titans at home.

Cardinals 30, Titans 6

Wood: This is the end of the road for Callahan. He may not even get to make the plane ride home.

Cardinals 38, Titans 6

Singh: Cam Ward will have a breakout game but Titans’ poor defense will be unable to hold the reign against Cardinals’ offense. Final nail in the coffin for Callahan as Cardinals will go 3-2 after week 5 win.

Cardinals 23, Titans 19

Lions (-10.5) at Bengals

Hubbard: So much has gone wrong for the Bengals this season. They lost Joe Burrow, and while Jake Browning is an experienced backup, he hasn’t looked good. The Bengals also can’t run the football with Chase Brown, who is getting hit behind the line of scrimmage on almost every run. While the Lions got beat up on pretty good in Week 1, they’ve bounced back nicely and should advance to 4-1 this weekend.

Lions 38, Bengals 13

Wood: This is more just about my wishing for Jameis Winston to be traded to Cincy after this debacle.

Lions 44, Bengals 2

Singh: Jared Goff’s offense is good, Bengals’ offense is bad. Lions will dominate against Bengals to hand then another big defeat, clear as day.

Lions 34, Bengals 8

Commanders at Chargers (-3)

Hubbard: Jayden Daniels should be back in action for the Commanders when they hit the road to face the Chargers this Sunday. The last time Jayden Daniels and Justin Herbert faced off, they were both in college and we were treated to a shootout. I expect both offense to put points on the board this weekend, but with Terry McLaurin and Noah Brown out, the Chargers get the home win.

Chargers 31, Commanders 25

Wood: Chargers. Nice return for Daniels and strong bounce back for Bolts.

Chargers 30, Commanders 27

Singh: Jim Harbaugh bounces back in LA with a win. Mariota is a good backup but Chargers will be motivated after a lackluster loss in NY.

Chargers 14, Commanders 8

Patriots at Bills (-8)

Hubbard: This is a game that, on the surface, the Bills should win by a lot. However, the Patriots are a bit sneaky. Drake Maye’s had a few good games, and the Patriots defense is nothing to laugh at. Buffalo should win, but I wouldn’t be surprised if the Pats give them a scare.

Bills 28, Patriots 23

Wood: Bills. I want to pick the Pats, I really do, just to make this division interesting. Alas, it is not to be.

Bills 33, Patriots 24

Singh: Drake Maye is good, but that said, Patriots will fail to beat the Bills while Josh Allen carries the offense.

Bills 19, Patriots 14

Chiefs (-3.5) at Jaguars

Hubbard: At the beginning of the season, this would be a seven-point spread in favor of the Chiefs, but they’ve gotten off to a slow start and the Jags are 3-1 through four weeks. With Xavier Worthy back last week, the Chiefs scored a season-high 37 points. Their offense should continue to roll through Jacksonville and cover easily.

Chiefs 31, Jaguars 20

Wood: This pick is for my fellow contestant on “The Floor,” Molly Sperling. Hope doesn’t always have to be lost on your Jags, Molly. Trevor ascends while the “Chiefs are back!” narrative hits a snag.

Jaguars 30, Chiefs 10

Singh: KC rising back toward Super Bowl contenders with a healthy offense. Worthy is back and once Rashee Rice returns, there’s no stopping them. Mahomes will not commit the same mistakes and it should be an easy win for the Chiefs.

Chiefs 20, Jaguars 12