This will be the first Dallas Cowboys game without Dak Prescott on their roster since 2016. The talented 27-year-old quarterback suffered a season-ending compound ankle fracture last weekend against the New York Giants.

Coach Mike McCarthy will hope that backup QB Andy Dalton will step in and lead his team to a win on Monday night.

Meanwhile, the Kyler Murray-led Arizona Cardinals will look to build on last week’s win over the New York Jets. The likes of DeAndre Hopkins and Larry Fitzgerald and others will look to cause all sorts of problems for the misfiring Cowboys defense at the AT&T Stadium.

Here’s a detailed look at both teams, along with injury updates and Week 6 game day predictions.

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NFL Preview

Dallas Cowboys will fight till the very end in honor of Dak Prescott

Head coach Mike McCarthy’s Dallas Cowboys are on a 2-3 record at this point in the league. They will be motivated to perform well tonight in light of Dak Prescott’s devastating injury in Week 5.

Veteran quarterback Andy Dalton will start tonight after seeing out a win in the league last weekend. In the absence of Dak, the responsibility to lead the charge will be shouldered by Ezekiel Elliott, Amari Cooper, and other senior team members.

Rookie WR CeeDee Lamb has been phenomenal, so far. He should be Dalton’s preferred attacking outlet on Monday night.

The Cowboys defense has been slacking all season now. They will need to be at their very best if they intend to stop dual-threat quarterback Kyler Murray.

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Will Kyler Murray lead the Cardinals to a much-needed win on Sunday?

Kliff Kingsbury has led the Arizona Cardinals to a 3-2 record over 5 games. Tonight’s game at the AT&T Stadium will offer the visitors a good chance to add to their tally for the season.

Last week’s win over the New York Jets will instill some confidence in the Cardinals dressing room after a mixed bag of results this season.

The Cardinals have a few injuries to their offensive line heading into this fixture. But seasoned WRs DeAndre Hopkins and Larry Fitzgerald will cause all sorts of problems to the Cowboys tonight.

Cardinals safety Budda Baker will also need to put in a strong display in order to stop Zeke, CeeDee Lamb, Amari Cooper, and Michael Gallup.

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NFL Preview: Dallas Cowboys vs Arizona Cardinals Injury Updates

Dallas – None

Arizona – Out

OLB Kylie Fitts – Hamstring

DT Rashard Lawrence – Calf

OG J.R. Sweezy – Elbow

Questionable

OLB Dennis Gardeck – Foot

DL D.J. Humphries – Back

OLB Devon Kennard – Calf

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Cowboys vs Cardinals Prediction

Dallas Cowboys 18 – 27 Arizona Cardinals

Apart from the obvious absence of Dak Prescott, the Cowboys have been inconsistent throughout the 2020 season. Their defense, in particular, has come under immense scrutiny in recent weeks.

Therefore, we feel Kyler Murray’s Arizona Cardinals will put the Cowboys in great jeopardy tonight.