Kyle Shanahan’s San Francisco 49ers have been dealing with multiple injury struggles in recent weeks. They suffered their second consecutive loss of the season last week against the Ryan Fitzpatrick-led Miami Dolphins. Jimmy Garoppolo and Co. will be desperate to get back to winning ways sooner rather than later.

Meanwhile, Sean McVay’s Los Angeles Rams continue to impress in the ongoing 2020 NFL season. The Rams enter this tie as firm favorites, having bested the Washington Football Team in Week Five.

Here’s a detailed look at both teams, along with injury updates and Week Six game day predictions.

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Kyle Shanahan’s San Francisco 49ers need to find some form this weekend

Coach Kyle Shanahan will be less than content with his team’s results over the last couple of weeks. They’ve been dealt some massive injury blows.

Star DE Nick Bosa was ruled out for the season with an ACL tear during the Week Two win over the New York Jets. Quarterback Jimmy Garoppolo was also out for a couple of weeks with an ankle sprain.

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The likes of George Kittle, Brandon Aiyuk, Jerick McKinnon, Kendrick Bourne, and Deebo Samuel will be pivotal for the 49ers in this home tie.

The defense will need to step up in the absence of Kwon Alexander and Dontae Johnson, who are both ruled out of tonight’s game.

Los Angeles Rams looking to maintain promising run in the league

The Los Angeles Rams are turning out to be the surprise package of this NFL season. They find themselves contending for a playoff spot with a 4-1 record after five games.

They will be desperate to sustain their form, especially with Jared Goff playing some eye-catching football. WR Cooper Kupp and Robert Woods will be essential in the offense.

However, the monstrous Aaron Donald along with CB Jalen Ramsey will be the focal points in defense on Sunday. The Rams will need to keep Garoppolo and Kittle out of the end zone at all costs.

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NFL Preview: San Francisco 49ers vs Los Angeles Rams Injury Updates

San Francisco – Out

LB Kwon Alexander – Ankle

CB Dontae Johnson – Groin

Questionable

S Marcell Harris – Ankle

CB Emmanuel Moseley – Concussion

RB Jeffery Wilson – Calf

Los Angeles – Out

LB Ogbonnia Okoronkwo  -Elbow

Questionable

LB Micah Kiser – Groin

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49ers vs Rams Prediction

San Francisco 49ers 29 – 34 Los Angeles Rams

We’re going with McVay’s Rams, who are clearly punching above their weight in the NFL this season. Their only loss this season came against Josh Allen’s Buffalo Bills in Week Three. They’ve been on a 2-game win streak since then and will definitely be looking to make that three tonight.

Meanwhile, the 49ers seem diminished following their massive injury overhaul. It will be tough for Shanahan’s boys to put a stop to this rampant Los Angeles Rams outfit.