The Kyle Shanahan-led San Francisco 49ers made their way to a much-needed win over the Los Angeles Rams last weekend. The Red and Gold pulled off a major upset despite missing some important names. Can they repeat the same antics in Week 13?

Meanwhile, Sean McDermott’s also returned to winning ways with a comfortable win over the Chargers in Week 12. They will look to build on that display as they push for the top spot in the AFC East Division.

Here’s a detailed look at both teams, along with injury updates and Week 13 Game Day predictions.

ALSO READ- NFL Insider Offers Tua Tagovailoa Update Ahead of Cincinnati Bengals Showdown

NFL Preview

Kyle Shanahan’s San Francisco 49ers looking to end 2020 on a high

It’s been a tough season so far for the 49ers. After last year’s Super Bowl run, the Niners are currently sitting at the bottom of the NFC West Division table.

They have 5 wins from 11 games in 2020 and are more or less out of the running for a playoff spot. In the absence of stars such as George Kittle, Jimmy Garoppolo, and Nick Bosa, the 49ers put in a strong performance to win their game against the Rams in Week 12.

Quarterback Nick Mullens will look to WR Deebo Samuel and Brandon Aiyuk for some help in the offensive department. But the emphasis will be on the 49ers’ defense to step up and take charge against a strong Buffalo attack led by the fearless Josh Allen. Coach Shanahan will be without CB K’Waun Williams for tomorrow’s game at the Levi’s Stadium.

Josh Allen-led Buffalo Bills mounting AFC East title run

Quarterback Josh Allen started the year with some eye-catching displays that earned him comparisons with Super Bowl MVP Patrick Mahomes.

Allen has more than 3,000+ passing yards with 22 passing TDs to his name in 2020. However, the youngster has been a tad bit inconsistent in recent weeks.

The Bills have a fully fit squad to choose from for this Week 13 away fixture in San Francisco. However, coach McDermott will be well aware of the need to rotate certain players in order to balance the workload.

ALSO READ- Popular Analyst Tips Ben Roethlisberger for MVP Along with Aaron Rodgers, Patrick Mahomes

NFL Preview: San Francisco 49ers vs Buffalo Bills Injury Updates

San Francisco – Out

CB K’Waun Williams – Ankle

Questionable

CB Emmanuel Mosely – Hamstring

Buffalo – None

49ers vs Bills Prediction

San Francisco 49ers 15 – 28 Buffalo Bills

Despite their surprise win in Week 13, we are going to back Josh Allen’s Buffalo Bills to walk away with this win. The Bills are a tough team to beat when they’re playing at their best. We expect nothing less from them on Sunday night.

Josh Allen has led the Bills to an 8-3 record this season. If he can improve on that tally at the end of Week 13 is something that we look forward to finding out this weekend.

ALSO READ- “If You Try Him, He’s Going to Try You” – Former Green Bay Packers Man Talks Up Aaron Rodgers