NFL Thanksgiving Weekend: Los Angeles Rams vs San Francisco 49ers Prediction and Analysis

November 28, 2020 7:40 pm

Sean McVay has led the Los Angeles Rams to a 7-3 record heading into Thanksgiving weekend. They are currently at the summit of the NFC West Division table ahead of Seattle Seahawks and Arizona Cardinals. They will be the obvious favourites as they gear up to host a hurting San Francisco 49ers outfit on Sunday.

It’s been a tough season for Kyle Shanahan and the 49ers, dealing with major injury problems to star players. However, it seems like star wide receiver Deebo Samuel might make a return in Week 12.

Here’s a detailed look at both teams, along with injury updates and Week 12 Game Day predictions.

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NFL Preview

The Jared Goff-led Los Angeles Rams looking to maintain winning run

The Rams pulled off a statement win last weekend against the Tampa Bay Buccaneers to jump to the top of their division. They will be backing themselves to hold on to that spot ahead of the clash against the 49ers.

Quarterback Jared Goff has proved to be a consistent performer this season. He will look to his star wide receivers, Cooper Kupp and Robert Woods, for some offensive support yet again.

Coach McVay will be sweating on the fitness of tight end Tyler Higbee, who is dealing with an elbow issue. The onus will be on Los Angeles Rams defensive stars Aaron Donald and Jalen Ramsey to stop the 49ers on Sunday at the Allegiant Stadium.

Kyle Shanahan’s San Francisco 49ers looking to end the season on a high

It’s been a season to forget for Kyle Shanahan and the rest of the Niners fanbase. After reaching the Super Bowl last season, the 49ers find themselves at the bottom of their division heading into Week 12 with almost no chance of making the Playoffs.

They are without their first-choice starters Jimmy Garoppolo, George Kittle, Nick Bosa and Raheem Mostert.

Nick Mullens will start at quarterback this weekend in Jimmy’s absence. However, one positive sign is the return of wide receiver Deebo Samuel, who is making a return from injury.

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NFL Preview: Los Angeles Rams vs San Francisco 49ers Injury Updates

Los Angeles – Questionable

TE Tyler Higbee  – Elbow

OL Brian Allen  – Knee


OLB Terrell Lewis  – Knee

San Francisco – Out

RB Tevin Coleman – Knee

OL Tom Compton – Concussion

LB Demetrius Flannigan-Fowles – Hamstring

CB K’Waun Williams – Ankle


LB Azeez Al-Shaair – Illness

LB Dre Greenlaw – Illness

DT Javon Kinlaw – Not injury related

TE Jordan Reed – Illness

Rams vs 49ers Prediction

Los Angeles Rams 27 – 17 San Francisco 49ers

Oct 26, 2020; Inglewood, California, USA; Los Angeles Rams defensive end Aaron Donald (99) and defensive end Michael Brockers (90) celebrate in the final minute against the Chicago Bears at SoFi Stadium. The Rams defeated the Bears 24-10. Mandatory Credit: Kirby Lee-USA TODAY Sports

The Rams are slowly but steadily mounting up a challenge to make the NFL Playoffs in 2020. They are leading the NFC West Division table against all odds and will be backing themselves to prove their doubters wrong over the course of the next 5 weeks.

The Rams have already defeated the 49ers once earlier this season. They should wrap this one up comfortably without much of struggle.

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