Serena is still the greatest of all time, and no one can take that away from her. I'm proud of her.

— Charlotte Clymer🏳️‍🌈 (@cmclymer) September 11, 2015

that person that beat serena look at least 59 years old.

— sean. (@Seantaneous) September 11, 2015

This isn't the time to be sad. Serena won 4 grand slams in a row. She didn't win the calendar slam but she went out fighting! #CHAMPION

— Kevin Simmons (@TheSkorpion) September 11, 2015

Hugs to all my Serena fans. I can't even imagine what y'all feeling right now. @JLR78 pic.twitter.com/rKwcYHGhta

— Erika (@SCWTA) September 11, 2015

The lesson: no matter who you are, you may be just one ebullient Italian lady away from disaster

— Bruce Arthur (@bruce_arthur) September 11, 2015

Serena: “I don’t want to talk about how disappointing this is for me. If you have another question I’ll answer that.”

— WTA Insider (@WTA_insider) September 11, 2015

I can't believe Serena lost! My heart is broken. pic.twitter.com/5FjkVBLLrM

— Chuck Nice (@chucknicecomic) September 11, 2015

Serena is one of the greatest if not the best ever! But brava @roberta_vinci such a talented&great player and a nice person too she deserves

— Kristina Mladenovic (@KikiMladenovic) September 11, 2015

We'll never be able to grasp extent of what Serena dealt w/ during this run. She remains a singular talent. Brava on an incredible journey.

— Jonathan Carey-Newman (@Tennis_Jon) September 11, 2015

Serena Williams is now 43-2 in her career against unseeded opponents at US Open.

— SportsCenter (@SportsCenter) September 11, 2015

When I heard Serena loss pic.twitter.com/tf2ObF1M17

— Mike Damn 🇯🇲 (@Mik3Anthony) September 11, 2015

Drake is already composing a Vinci diss track just in case

— Bruce Arthur (@bruce_arthur) September 11, 2015

DAMN SERENA GOT WASHED BY A LADY WHO DEFINITELY BUYS TROUSERS AT ANN TAYLOR

— THE KID MERO 🇩🇴 (@THEKIDMERO) September 11, 2015

With Serena loss, ticket prices for women's final are plummeting like I've never seen

— Darren Rovell (@darrenrovell) September 11, 2015

Please disembark the Serena bandwagon in a calm and orderly manner and be careful for items that may have shifted in the overhead bins.

— Sam Laird (@samcmlaird) September 11, 2015

If Roberta Vinci could win against Serena Williams in a grand slam, maybe even I could have a chance to someday understand women

— The Bad Doctor (@DOCTORATLARGE) September 11, 2015

Waking up from a nap… And Serena lost. 😔😔

— stefanie Dolson (@bigmamastef) September 11, 2015

I hope Serena feels the millions of us who are sending her love and hugs and know that we are not disappointed in her. Not at all.#serena

— Terry McMillan (@MsTerryMcMillan) September 11, 2015

Add it to my "Queen Serena" GIF folder pic.twitter.com/73HrUn08ZI

— Jarett Wieselman (@JarettSays) September 11, 2015

Heartbroken for Serena but she will always be my favorite champion.

— Kelly McCreary (@KellyMcCreary) September 11, 2015

Serena's mother Oracene said she thought the pressure of expectations got to Serena today.

— Jane McManus (@janesports) September 11, 2015

Average list price to women's final before Serena match today: $1,412 a ticket. Avg list price now? $680, says @TiqIQ

— Darren Rovell (@darrenrovell) September 11, 2015

I normally make fun of people that get super into sports but here i am crying at work over Serena losing so joke's on me

— alexa (@actuallyalexa) September 11, 2015

Roberta Vinci defeated Serena Williams. Any attempts to link this statement to Leonardo da Vinci & Monalisa is an exercise in hopelessness.

— Roflindian (@Roflindian) September 11, 2015

"I never felt pressure. I never felt pressure playing this tournament." – Serena #usopen

— US Open Tennis (@usopen) September 11, 2015

Feelings about Serena. pic.twitter.com/7BFS2EqB97

— WNYC 🎙 (@WNYC) September 11, 2015

No tears from Serena. Anyone who remembers her younger years has seen edgier pressers from her. But she kept it brief and businesslike

— Christopher Clarey (@christophclarey) September 11, 2015

I was really looking forward to Serena's Grand Slam. She is one of the greatest athletes who ever lived. Next year, beautiful girl.

— Bette Midler (@BetteMidler) September 11, 2015

Serena Williams upset in US Open semifinals and everyone is blaming Drake #BlameDrake: http://t.co/kzQrd0Kiqa pic.twitter.com/5wU5CdY42u

— SneakerMob.com (@SneakerMob) September 11, 2015

Twitter blaming Drake for Serena Williams losing the US Open Semis. pic.twitter.com/OlAf5QyXQR

— WORLDSTARHIPHOP (@WORLDSTAR) September 11, 2015

Serena was over the post-match presser even before it started: "I don't want to talk about how disappointing it is." pic.twitter.com/CmNDLuuHTT

— Romi Cvitkovic (@RomiCvitkovic) September 11, 2015

Wow the power of Serena. The women's finals tix now as low as $40.

— SallieMaeSux! (@BlkThemyscira) September 11, 2015

More surprising than Serena losing is how many people there are pretending they're tennis fans.

— The Guy (@theguydf) September 11, 2015

Where was Beyoncé to warn Serena away from Kim Kardashian?!

Everyone failed!

— Genie Lauren (@MoreAndAgain) September 11, 2015

"I did win three Grand Slams this year. Yeah, I won 4 in a row. It's pretty good."—Serena #USOpen

— Steve Tignor (@SteveTignor) September 11, 2015

Not even Roberta Vinci thought she could beat Serena Williams. http://t.co/DZsbRpRCaK

— SportsCenter (@SportsCenter) September 11, 2015